Key Takeaways:
Medspas used to be Hollywood’s worst-kept secret. Paparazzi often snapped photographs of celebrities leaving out the back door, disguised in sunglasses and a hat to cover their red faces following a laser or chemical peel. Today, medspas are no longer a shameful secret that only caters to the ultra-wealthy. These facilities can now be found in strip malls across cities of all sizes, proving that the modern medspa market has evolved from niche to mainstream. Fueled by consumer demand for preventative treatments, minimally invasive procedures, and results-driven skincare, medspas are one of the hottest franchise models to invest in today.
As of 2023, the number of medical spas surged to 10,488, with the average location generating a staggering $1.39 million in annual revenue, according to the American Med Spa Association. Globally, the medspa market brought in $21.21 billion in 2024 and is projected to increase to $78.23 billion by 2033, growing at a CAGR of 15.77% from 2025 to 2033. Even private equity has started to take notice, drawn in by the large number of businesses ripe for consolidation in a highly fragmented market. In 2024, private equity firm Freeman Spogli took a majority stake in VIO Med Spa with plans to expand to over 50 VIO locations by the end of the year.
For entrepreneurs, medspa franchises offer entry into a high-growth category with recurring revenue potential, membership models, and strong margins on services like injectables, laser treatments, and advanced facials. But in order to achieve such great returns, owners will have to navigate complex federal and state regulations, medical oversight, and invest significant capital to get these facilities off the ground. For operators willing to navigate the regulatory and operational complexities, the medspa franchise market presents a compelling business opportunity, particularly as consumers increasingly treat injectables, laser treatments, and advanced facials as routine maintenance rather than rare indulgence.
Below, BeautyMatter rounds up some of the top medspa franchises to help prospective owners evaluate the investment, scale potential, and operational support powering this booming industry.
VIO Med Spa
Founded: 2017
Minimum Liquidity Requirement: $285,000-$400,000
Minimum Net Worth Requirement: $1,500,000
Initial Investment Range: $794,261-$1,231,677
Franchise Fee: $50,000
Number of Locations: 60+
Royalty Fee: 6%
Founded in 2017 in Strongsville, Ohio, VIO Med Spa has a nationwide presence with over 60 locations across 20 states. The company nabbed the top spot in Entrepreneur Magazine's Franchise 500 ranking of top medspas for the third consecutive year in 2025. The brand, whose name stands for "value in ourselves,” operates under a physician-guided model offering a robust suite of noninvasive aesthetic and wellness treatments, supported by a membership program that drives reliable recurring revenue. Franchisees benefit from comprehensive training, in-house marketing support, and a scalable multi-unit model. No medical background is required to own a VIO Med Spa franchise. VIO Med Spa is actively expanding and recently relocated its headquarters to Nashville, Tennessee, to support its next phase of growth.
GLO30
Founded: 2012
Minimum Liquidity Requirement: $500,000
Minimum Net Worth Requirement: $1,000,000
Initial Investment Range: $430,500-$734,500
Franchise Fee: $45,000
Number of Locations: 30+
Royalty Fee: 6%
GLO30 has carved out a distinct niche by bridging everyday day spas and clinical medspas since its 2012 launch in Washington, D.C. Its signature offering is a monthly, customized facial powered by GLOria, a proprietary AI-driven skin analysis tool. The subscription-based membership model, with treatments offered every 30 days, generates strong recurring revenue in a compact 500-1,200-square-foot footprint, with no heavy equipment buildouts required. Franchisees don't need a medical or skincare background; the brand provides full employee training in under two weeks. GLO30 is targeting aggressive national expansion with 100+ locations currently in development.
Dermani MEDSPA
Founded: 2013
Minimum Liquidity Requirement: $250,000
Minimum Net Worth Requirement: $1,000,000
Initial Investment Range: $386,486-$795,247
Franchise Fee: $55,000
Number of Locations: 30+
Royalty Fee: 5%
Dermani MEDSPA is built on a high-value, membership-based model that aims to make luxury medical aesthetic services accessible to the masses. The company operates three-tiered membership programs focused on skin rejuvenation, aesthetic treatments, and laser hair removal. Their "all-inclusive" membership approach ensures consistent, predictable revenue for franchisees while offering clients significant savings. Each location operates under medical director supervision, and the brand actively supports franchisees in establishing physician partnerships.
Serotonin Centers
Founded: 2021
Minimum Liquidity Requirement: $500,000
Minimum Net Worth Requirement: $2,000,000
Initial Investment Range: $872,284-$1,788,879
Franchise Fee: $59,000
Number of Locations: 16+
Royalty Fee: 7%
Founded by industry veteran and serial entrepreneur Eric Casaburi, who previously founded Retro Fitness, Casaburi brought his franchise instincts to the longevity space when he launched Serotonin Centers in 2021. Operating in a concierge model, each center pairs licensed medical practitioners with personal health coaches to deliver personalized "healthspan" roadmaps. Services span hormone replacement therapy, medical weight loss, Botox and fillers, body contouring, IV drip therapy, red light therapy, and hyperbaric oxygen therapy. Locations are typically situated in high-end retail corridors alongside upscale grocers and fitness tenants.
Alexis Lauren
Founded: 2022
Minimum Liquidity Requirement: $500,000
Minimum Net Worth Requirement: $1,500,000
Initial Investment Range: $835,525-$1,362,800
Franchise Fee: $50,000
Number of Locations: 2+
Royalty Fee: 6%
Ultra-luxe, female founder-led, and Miami-born, Alexis Lauren reimagines the traditional med- spa as a luxury, community-centered business where hospitality matters as much as the treatments. Launched in 2022 by Alexis Renda, the brand offers personalized, medical-grade services—injectables, facials, laser, microneedling, platelet-rich plasma (PRP), and more—through a curated menu designed to eliminate decision fatigue. Its proprietary membership program, The Vault, functions like a fitness-style prepaid model, driving retention and predictable franchisee revenue. Two corporate Miami locations report an average unit volume of $1.89 million. Alexis Lauren is seeking operators in Texas, with Austin and Dallas identified as priority markets for franchise growth.
4Ever Young
Founded: 2014
Minimum Liquidity Requirement: $400,000
Minimum Net Worth Requirement: $1,000,000
Initial Investment Range: $386,750-$747,400
Franchise Fee: $60,000
Number of Locations: 74+
Royalty Fee: 7%
4Ever Young aims to help clients look and feel their best as they age. The membership-based anti-aging clinic offers a huge selection of services across aesthetics, hormone optimization, IV nutrition, weight loss, and body performance. 4Ever Young positions itself at the intersection of the wellness and aesthetic industry. By offering a wide range of services under one roof, 4Ever Young maximizes customer convenience while providing franchisees with diversified revenue streams and multiple opportunities for upselling and recurring treatment plans.
Facial Mania Med Spa
Founded: 2014
Minimum Liquidity Requirement: $150,000
Minimum Net Worth Requirement: $400,000
Initial Investment Range: $312,000-864,000
Franchise Fee: $69,000
Number of Locations: 11+
Royalty Fee: 6%
Facial Mania Med Spa offers a flexible, tiered model that makes premium medspa care accessible to every budget. The brand offers injectables, laser treatments, and advanced facials, alongside curated skincare retail. Designed to appeal to a broad demographic, Facial Mania Med Spa emphasizes transparent pricing, treatment customization, and membership-style programs to encourage repeat visits. Clinics operate under medical oversight while franchisees focus on operational management and local marketing. With a balanced service mix spanning both high-ticket injectables and lower-priced, recurring skin treatments, the model supports diversified revenue streams at a price that remains accessible to a wide range of consumers.
Liquivida Lounge
Founded: 2013
Minimum Liquidity Requirement: $150,000
Minimum Net Worth Requirement: $500,000
Initial Investment Range: $645,375-$929,600
Franchise Fee: $75,000
Number of Locations: 18+
Royalty Fee: 6%
Liquivida Lounge was among the first to put drip wellness on the mainstream map when founder Samael Tejada launched the Fort Lauderdale-based brand in 2013, long before IV bars became ubiquitous. Over a decade later, the brand has evolved into a full-service wellness and medspa franchise covering aesthetics, hormone optimization, medical weight loss, and lifestyle management under its signature "Vida Journey" framework. Franchisees receive a six-month training program plus three months of post-launch business coaching, and the cash-based model (no insurance) keeps operations streamlined. The franchise is available as both a standalone wellness center and an integrated add-on for existing businesses.
C3 Wellness Spa
Founded: 2020
Minimum Liquidity Requirement: $653,000+
Minimum Net Worth Requirement: $1,00,000
Initial Investment Range: $653,000+
Franchise Fee: $45,000
Royalty Fee: 6%
The three C’s in C3 Wellness Spa stand for connect, care, and cure. These three principles inform everything from C3 Wellness Spa’s treatment philosophy to its broad service menu. Crystal Bethea's Florida-born concept blends Eastern and Western practices under one roof, offering cosmetic injectables, IV infusion therapy, body contouring, and permanent makeup alongside acupuncture, massage, yoga, and Pilates. One of the brand's standout differentiators is that it accepts major medical insurance and VA benefits for applicable services, meaningfully expanding its potential client base. The scalable franchise model allows owners to start with core services and expand over time.
Face to Face Spa
Founded: 2011
Minimum Liquidity Requirement: $145,000
Minimum Net Worth Requirement: $750,000
Initial Investment Range: $485,000+
Franchise Fee: $39,000
Number of Locations: 41+
Royalty Fee: 5%
After struggling with severe cystic acne, founder Jenny Woodcock launched Face to Face Spa in Austin, Texas, in 2011 with a clear mission to place equal emphasis on both results and relaxation. The membership-based brand focuses exclusively on skin health, with a goal-oriented menu spanning medical-grade facials, chemical peels, HydraFacials, Botox, fillers, lashes, and medical weight loss via semaglutide injections. Each location requires approximately 2,000 square feet with six to nine treatment rooms. Franchisees receive 120 hours of classroom training, 40 hours of on-site training, and ongoing support to ensure success.